Zen Night Ingredients:
Theirs Benefits and Supporting Citations

  • MELATONIN – Improves sleep onset and duration for more restful and refreshing sleep (1, 2, 3, 4, 5, 6)
  • VALERIAN – Improves sleep quality by enhancing deep sleep (7, 8, 9, 10, 11, 26)
  • GABA – Inhibitory neurotransmitter that promotes sleep and restful sleep quality (12, 13, 14, 15, 16, 17)
  • CHAMOMILE – Helps reduce sleep latency for ease of falling asleep (18, 19)
  • PASSION FLOWER – Reduces anxiety to allow better sleep quality (19, 20, 21, 22, 23)
  • LEMON BALM – Helps calm anxiety and produces a sedative effect (24, 25, 26, 27)
  • HOPS – Increases sleep duration and reduces awakenings through its sedative effect (10, 28, 29, 30, 31)
  • L-TRYPTOPHAN – Produces a sedative effect for improved sleep quality (32, 33, 34, 35, 36)
  • 5-HTP – Improves sleep onset, duration, and quality through increased levels of serotonin (25, 37, 38, 39)
  • PYRIDOXINE – Vitamin B6 – Supports good sleep quality by supporting healthy nerve function (40, 41)

Supporting Clinical Research

  1. Curr Opin Psychiatry. 2013 Nov;26(6):580-5. “Delayed sleep phase disorder in youth.”  Gradisar M, Crowley SJ.

  2. PLoS One. 2013 May 17;8(5):e63773  “Meta-analysis: melatonin for the treatment of primary sleep disorders.”  Ferracioli-Oda E, Qawasmi A, Bloch MH.

  3. Eur J Nutr. 2012 Dec;51(8):909-16.  “Effect of tart cherry juice (Prunus cerasus) on melatonin levels and enhanced sleep quality.”  Howatson G, Bell PG, Tallent J, Middleton B, McHugh MP, Ellis J.

  4. Int J Neurosci. 2009;119(6):821-46..  “Melatonin and melatonergic drugs on sleep: possible mechanisms of action.”  Srinivasan V, Pandi-Perumal SR, Trahkt I, Spence DW, Poeggeler B, Hardeland R, Cardinali DP.

  5. Biomed Sci Instrum. 2012;48:202-9.  “Modeling the effect of exogenous melatonin on the sleep-wake switch.”  Johnson N, Jain G, Sandberg L, Sheets K.

  6. J Neuroendocrinol. 2003 Apr;15(4):432-7.  “Role of melatonin in the regulation of human circadian rhythms and sleep.”  Cajochen C, Kräuchi K, Wirz-Justice A.

  7. Acta Med Port. 2011 Dec;24 Suppl 4:961-6.  “Use of valerian in anxiety and sleep disorders: what is the best evidence?”  Nunes A, Sousa M.

  8. Phytomedicine. 2012 Jul 15;19(10):924-9.  “Valeriana wallichii root extract improves sleep quality and modulates brain monoamine level in rats.”  Sahu S, Ray K, Yogendra Kumar MS, Gupta S, Kauser H, Kumar S, Mishra K, Panjwani U.

  9. J Psychopharmacol. 2005 Jul;19(4):414-21.  “Medicinal plants for insomnia: a review of their pharmacology, efficacy and tolerability.”  Wheatley D.

  10. Eur J Med Res. 2008 May 26;13(5):200-4.  “Sleep improving effects of a single dose administration of a valerian/hops fluid extract – a double blind, randomized, placebo-controlled sleep-EEG study in a parallel design using electrohypnograms.”  Dimpfel W, Suter A.

  11. Phytomedicine. 2010 Jul;17(8-9):674-8.  “Valeriana officinalis root extracts have potent anxiolytic effects in laboratory rats.”  Murphy K, Kubin ZJ, Shepherd JN, Ettinger RH.

  12. J Exp Biol. 2013 Oct 15;216(Pt 20):3837-43.  “GABAB receptors play an essential role in maintaining sleep during the second half of the night in Drosophila melanogaster.”  Gmeiner F, Kolodziejczyk A, Yoshii T, Rieger D, Nässel DR, Helfrich-Förster C.

  13. Curr Psychiatry Rep. 2013 Nov;15(11):405.  “Neuroimaging studies in insomnia.”  Spiegelhalder K, Regen W, Baglioni C, Riemann D, Winkelman JW.

  14. Sleep Med. 2013 Aug;14(8):714-8.  “New aspects in the pathophysiology of rapid eye movement sleep behavior disorder: the potential role of glutamate, gamma-aminobutyric acid, and glycine.”  Luppi PH, Clément O, Valencia Garcia S, Brischoux F, Fort P.

  15. J Ginseng Res. 2012 Oct;36(4):403-10.  “Repeated Administration of Korea Red Ginseng Extract Increases Non-Rapid Eye Movement Sleep via GABAAergic Systems.”  Lee CI, Kim CS, Han JY, Oh EH, Oh KW, Eun JS.

  16. Sleep Med. 2007 Jun;8(4):291-301.  “Hypothalamic control of sleep.”  Szymusiak R, Gvilia I, McGinty D.

  17. Cell Mol Life Sci. 2007 May;64(10):1187-204.  “Neuroanatomy and neurochemistry of sleep.”  Stenberg D.

  18. BMC Complement Altern Med. 2011 Sep 22;11:78. doi: 10.1186/1472-6882-11-78.  “Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: a randomized placebo-controlled pilot study.”  Zick SM, Wright BD, Sen A, Arnedt JT.

  19. Biol Pharm Bull. 2005 May;28(5):808-10.  “Hypnotic activities of chamomile and passiflora extracts in sleep-disturbed rats.”  Shinomiya K, Inoue T, Utsu Y, Tokunaga S, Masuoka T, Ohmori A, Kamei C.

  20. J Ethnopharmacol. 2013 Jul 30;148(3):812-7.  “Cycloartane triterpenoid saponins from water soluble of Passiflora edulis Sims and their antidepressant-like effects.”  Wang C, Xu FQ, Shang JH, Xiao H, Fan WW, Dong FW, Hu JM, Zhou J.

  21. Eur Neuropsychopharmacol. 2011 Dec;21(12):841-60. “Herbal medicine for depression, anxiety and insomnia: a review of psychopharmacology and clinical evidence.”  Sarris J, Panossian A, Schweitzer I, Stough C, Scholey A.

  22. Phytother Res. 2011 Aug;25(8):1153-9.  “A double-blind, placebo-controlled investigation of the effects of Passiflora incarnata (passionflower) herbal tea on subjective sleep quality.”  Ngan A, Conduit R.

  23. Wien Med Wochenschr. 2002;152(15-16):404-6.  “Passion Flower (Passiflora incarnata L.)–a reliable herbal sedative.”  Krenn L.

  24. Neuropsychopharmacology. 2003 Oct;28(10):1871-81.  “Modulation of mood and cognitive performance following acute administration of single doses of Melissa officinalis (Lemon balm) with human CNS nicotinic and muscarinic receptor-binding properties.”  Kennedy DO, Wake G, Savelev S, Tildesley NT, Perry EK, Wesnes KA, Scholey AB.

  25. Med Sci Monit. 2009 Nov;15(11):RA256-62.  “Formulations of dietary supplements and herbal extracts for relaxation and anxiolytic action: Relarian.”  Weeks BS.

  26. Phytother Res. 2006 Feb;20(2):96-102.  “Anxiolytic effects of a combination of Melissa officinalis and Valeriana officinalis during laboratory induced stress.”  Kennedy DO, Little W, Haskell CF, Scholey AB.

  27. Can J Physiol Pharmacol. 2007 Sep;85(9):933-42.  “Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system.”  Awad R, Levac D, Cybulska P, Merali Z, Trudeau VL, Arnason JT.

  28. Indian J Pharmacol. 2013 Jan-Feb;45(1):34-9.  “Efficacy and safety of a polyherbal sedative-hypnotic formulation NSF-3 in primary insomnia in comparison to zolpidem: a randomized controlled trial.”  Maroo N, Hazra A, Das T.

  29. Acta Physiol Hung. 2012 Jun;99(2):133-9.  “The sedative effects of hops (Humulus lupulus), a component of beer, on the activity/rest rhythm.”  Franco L, Sánchez C, Bravo R, Rodriguez A, Barriga C, Juánez JC.

  30. Phytomedicine. 2006 Sep;13(8):535-41.  “Sedating effects of Humulus lupulus L. extracts.”  Schiller H, Forster A, Vonhoff C, Hegger M, Biller A, Winterhoff H.

  31. Wien Med Wochenschr. 2007;157(13-14):367-70.  “Scientific evidence for a fixed extract combination (Ze 91019) from valerian and hops traditionally used as a sleep-inducing aid.”  Brattström A.

  32. Eur J Neurosci. 2012 Jun;35(11):1762-70.  “Novel biochemical manipulation of brain serotonin reveals a role of serotonin in the circadian rhythm of sleep-wake cycles.”  Nakamaru-Ogiso E, Miyamoto H, Hamada K, Tsukada K, Takai K.

  33. Age (Dordr). 2013 Aug;35(4):1277-85.  “Tryptophan-enriched cereal intake improves nocturnal sleep, melatonin, serotonin, and total antioxidant capacity levels and mood in elderly humans.”  Bravo R, Matito S, Cubero J, Paredes SD, Franco L, Rivero M, Rodríguez AB, Barriga C.

  34. Int J Tryptophan Res. 2009;2:23-36.  “Assessment of the Potential Role of Tryptophan as the Precursor of Serotonin and Melatonin for the Aged Sleep-wake Cycle and Immune Function: Streptopelia Risoria as a Model.”  Paredes SD, Barriga C, Reiter RJ, Rodríguez AB.

  35. Neurosci Biobehav Rev. 2010 Mar;34(3):387-407.  “Effects of tryptophan loading on human cognition, mood, and sleep.”  Silber BY, Schmitt JA.

  36. Am J Ther. 2010 Mar-Apr;17(2):133-9.  “A randomized, placebo-controlled trial of an amino acid preparation on timing and quality of sleep.”  Shell W, Bullias D, Charuvastra E, May LA, Silver DS.

  37. Sleep. 2010 Mar;33(3):307-14.  “Sleep and rhythm consequences of a genetically induced loss of serotonin.”  Leu-Semenescu S, Arnulf I, Decaix C, Moussa F, Clot F, Boniol C, Touitou Y, Levy R, Vidailhet M, Roze E.

  38. Neuroscience. 2000;95(2):445-52.  “5-Hydroxytryptophan, but not L-tryptophan, alters sleep and brain temperature in rats.”  Imeri L, Mancia M, Bianchi S, Opp MR.

  39. Altern Med Rev. 1998 Aug;3(4):271-80.  “5-Hydroxytryptophan: a clinically-effective serotonin precursor.”  Birdsall TC.

  40. Percept Mot Skills. 2002 Feb;94(1):135-40.  “Effects of pyridoxine on dreaming: a preliminary study.”  Ebben M, Lequerica A, Spielman A.

  41. “Nutrition Concepts and Controversies (6th Edition)”  F. Sizer and E Whitney, West Publishing Company, 1994, Chapter 13: 478-517.

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